Fish farming facilities are rapidly intensifying their operations in order to meet the increased demand for aquaculture products worldwide. As a result, fish farming populations are exposed to increased stressors such as higher bacterial load and higher incidence of injury, leading to higher incidences of mortalities. Immunomodulators can improve an organism’s response to stress by augmenting the immune response via enhancement or inhibition. However, the use of immunomodulators is an emerging concept in the aquaculture industry, and therefore potential immunomodulators must be effectively assessed. The purpose of this thesis was to develop a comprehensive immune microbe-associated molecular pattern (MAMP) challenge using larval zebrafish as a model organism, utilize said immune challenge to assess the immunomodulatory efficacy of 6-gingerol, and assess whether 6-gingerol could also improve healing after tissue trauma.